K63-linkage Specific Polyubiquitin Rabbit Polyclonal Antibody (CAB18164)
The K63-Linkage Specific Polyubiquitin Rabbit Polyclonal Antibody (CAB18164) is a valuable tool for researchers studying the K63-linked polyubiquitin chains involved in cellular signaling pathways. This antibody, raised in rabbits, specifically recognizes the K63-linked polyubiquitin chains and is highly reactive with human samples. Validated for use in Western blot applications, this antibody enables the detection and analysis of K63-linked polyubiquitin chains in various cell types.K63-linked polyubiquitin chains play a critical role in diverse cellular processes, including DNA repair, protein degradation, and immune responses.
Dysregulation of K63-linked polyubiquitination has been implicated in various diseases, such as cancer, neurodegenerative disorders, and inflammatory conditions. Therefore, investigating the function and regulation of K63-linked polyubiquitin chains is essential for understanding disease mechanisms and developing targeted therapies.Overall, the K63-Linkage Specific Polyubiquitin Rabbit Polyclonal Antibody (CAB18164) is a valuable tool for researchers interested in unraveling the complexities of cellular signaling pathways and exploring the therapeutic potential of targeting K63-linked polyubiquitination in disease contexts.
Product Name:
K63-linkage Specific Polyubiquitin Rabbit Polyclonal Antibody
SKU:
CAB18164
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat,Other (Wide Range Predicted)
Immunogen:
A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K63 linkage).
Tested Applications:
ELISADB
Recommended Dilution:
DB,1:500 - 1:1000
Positive Sample:
HeLa,HeLa+MG132,NIH/3T3,C6,Mouse brain,Rat brain
Observed MW:
15-200kDa
Ubiquitination,onetypeofthemostcommonpost-translationalmodification,mediatestheregulationofproteinhomeostasisinvivo.SinceubiquitinitselfcontainsmultiplelysineresiduesandoneN-terminalfreeaminogroup,eighttypesofubiquitinchainscanbeformed.? K63-linked polyubiquitin chains exert nonproteolytic functions in vivo, such as protein trafficking, kinase/phosphatase activation, and DNA damage control, all of which might be important in regulation of cancer survival and development （PMID: 19217402，PMCID: PMC3008764）.
Purification Method:
Affinity purification
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Dot-blot analysis of all sorts of peptides using K63-linkage Specific Polyubiquitin antibody (CAB18164) at 1:1000 dilution.
