K27-linkage Specific Polyubiquitin Rabbit Polyclonal Antibody (CAB18202)
- SKU:
- CAB18202
- Product Type:
- Antibody
- Reactivity:
- Universal
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | K27-linkage Specific Polyubiquitin Rabbit Polyclonal Antibody |
SKU: | CAB18202 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K27 linkage). |
Tested Applications: | WB ELISA DB |
Recommended Dilution: | WB,1:500 - 1:2000 DB,1:500 - 1:1000 |
Positive Sample: | NIH/3T3,RAW264.7,C6,Mouse brain,Mouse kidney |
Ubiquitination, one type of the most common post-translational modification, mediates the regulation of protein homeostasis in vivo. Since ubiquitin itself contains multiple lysine residues and one N-terminal free amino group, eight types of ubiquitin chains can be formed. The K27 ubiquitin chain is formed through the ubiquitination of the ubiquitin Lys27 (K27), which adopts a compact conformation. In recent years, biological function of the K27 ubiquitin chain in innate immunity, protein homeostasis and DNA damage has been discovered, but the molecular mechanisms of K27 ubiquitin chain assembly, recognition and hydrolysis are still poorly understood.
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |