The K-Cadherin Rabbit Monoclonal Antibody (CAB4689) is a highly specific and sensitive tool for studying K-Cadherin, a critical cell adhesion molecule involved in various cellular processes such as cell polarity, tissue organization, and cell migration. This monoclonal antibody, generated in rabbits, exhibits strong reactivity with human samples and is validated for use in immunofluorescence and immunohistochemistry applications.K-Cadherin, also known as cadherin-6, plays a fundamental role in maintaining tissue integrity and architecture by mediating cell-cell adhesion. Dysregulation of K-Cadherin expression has been implicated in developmental disorders and various cancers, highlighting its importance in physiological and pathological conditions. The CAB4689 antibody enables precise detection and visualization of K-Cadherin expression, making it an invaluable tool for researchers investigating cell adhesion mechanisms, developmental biology, and cancer progression.
By utilizing the K-Cadherin Rabbit Monoclonal Antibody (CAB4689), researchers can gain valuable insights into the function and localization of K-Cadherin in different cell types and tissues, advancing our understanding of its role in cell adhesion and migration processes. This antibody is essential for studies aiming to unravel the molecular mechanisms underlying cell-cell interactions and tissue organization, with potential implications in the development of targeted therapies for conditions associated with aberrant K-Cadherin activity.
Product Name:
K-Cadherin (CDH6) Rabbit Monoclonal Antibody
SKU:
CAB4689
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 691-790 of human K-Cadherin (CDH6) (P55285).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
88kDa
Observed MW:
130kDa
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis.
Purification Method:
Affinity purification
Gene ID:
1004
Clone Number:
ARC1093
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using K-Cadherin (CDH6) Rabbit mAb (CAB4689) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
