The JRK Antibody (PAC062439) is a polyclonal antibody designed for research involving JRK, a protein involved in various cellular processes such as cell growth, proliferation, and differentiation. The antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in immunofluorescence and immunohistochemistry applications.JRK, also known as Janus Kinase-related kinase, is a key player in signaling pathways that regulate cell survival and apoptosis. Its role in cell signaling makes it a target of interest in cancer research, as dysregulation of JRK has been linked to various cancers.
By targeting the JRK protein, researchers can gain insights into the mechanisms underlying cancer development and potentially identify new therapeutic targets for cancer treatment.The JRK Antibody (PAC062439) is a valuable tool for studying JRK expression and localization in different cell types and tissues, providing researchers with crucial information for understanding the role of JRK in disease processes. Its specificity and sensitivity make it an ideal choice for investigating the functions of JRK in cell biology and cancer research.
Antibody Name:
JRK Antibody (PACO62439)
Antibody SKU:
PACO62439
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Peptide sequence from Human Jerky protein homolog protein (465-483AA)
Western Blot. Positive WB detected in: SH-SY5Y whole cell lysate, Mouse heart tissue. All lanes: JRK antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 62, 63 kDa. Observed band size: 62 kDa.
Background:
May bind DNA.
Synonyms:
Jerky protein homolog, JRK, JH8
UniProt Protein Function:
May bind DNA.
UniProt Protein Details:
NCBI Summary:
This gene encodes a conserved protein that is similar to DNA-binding proteins, such as major centromere autoantigen B (CENPB). Inactivation of the related gene in mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
