The JPH1 Polyclonal Antibody (CAB18476) is a research tool designed for investigating Junctophilin-1 (JPH1), a protein involved in the formation of junctional complexes in cells. Raised in rabbits, this antibody is highly specific and reactive with human samples, making it suitable for use in Western blot applications. By binding to JPH1, researchers can detect and analyze this protein in various cell types, making it an ideal tool for studies in cell biology and neuroscience.JPH1 is known for its role in organizing membrane structures in cells, specifically in the junctions between the plasma membrane and the endoplasmic/sarcoplasmic reticulum. This unique function makes JPH1 a key player in maintaining cellular structure and communication.
Research on JPH1 can provide insights into cell physiology and the mechanisms underlying cellular functions such as calcium signaling and membrane dynamics.Studying JPH1 is particularly relevant in the fields of muscle biology, neuroscience, and cardiovascular research, where junctional complexes play critical roles in muscle contraction, neuronal signaling, and cardiac function. By understanding the function and regulation of JPH1, researchers can gain valuable knowledge that may lead to the development of novel therapies for diseases related to cellular dysfunction and communication.
Product Name:
JPH1 Rabbit Polyclonal Antibody
SKU:
CAB18476
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 410-640 of human JPH1 (NP_065698.1).
junctional membrane complex, nucleoplasm, plasma membrane, sarcoplasmic reticulum, Z disc
Calculated MW:
72kDa
Observed MW:
62kDa
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
Purification Method:
Affinity purification
Gene ID:
56704
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse skeletal muscle, using JPH1 Rabbit pAb (CAB18476) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
