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JNK3 Polyclonal Antibody (CAB2112)

SKU:
CAB2112
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$155 - $431
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:JNK3 Polyclonal Antibody
SKU:CAB2112
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 175-464 of human JNK3 (NP_620448.1).
Sequence:CGIK HLHS AGII HRDL KPSN IVVK SDCT LKIL DFGL ARTA GTSF MMTP YVVT RYYR APEV ILGM GYKE NVDI WSVG CIMG EMVR HKIL FPGR DYID QWNK VIEQ LGTP CPEF MKKL QPTV RNYV ENRP KYAG LTFP KLFP DSLF PADS EHNK LKAS QARD LLSK MLVI DPAK RISV DDAL QHPY INVW YDPA EVEA PPPQ IYDK QLDE REHT IEEW KELI YKEV MNSE EKTK NGVV KGQP SPSG AAVN SSES LPPS SSVN DISS MSTD QTLA SDTD SSLE ASAG PLGC CR
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
Positive Sample:Mouse brain,Mouse testis
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus.
Calculated MW:44kDa
Observed MW:48kDa

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

Purification Method:Affinity purification
Gene ID:5602
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using JNK3 antibody (CAB2112) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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