The JNK3 Polyclonal Antibody (CAB2112) is specifically designed for research involving JNK3, a key protein kinase in the c-Jun N-terminal kinase (JNK) signaling pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It binds specifically to the JNK3 protein, enabling the detection and analysis of its expression in various cell types.JNK3 plays a crucial role in cell proliferation, differentiation, and apoptosis, making it a valuable target for research in the fields of cell biology, neuroscience, and cancer biology.
Understanding the function and regulation of JNK3 can provide insights into various cellular processes and pathological conditions. The use of the JNK3 Polyclonal Antibody in experiments can aid in unraveling the complexity of the JNK signaling pathway and its implications in disease development and progression.
Product Name:
JNK3 Polyclonal Antibody
SKU:
CAB2112
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 175-464 of human JNK3 (NP_620448.1).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
Purification Method:
Affinity purification
Gene ID:
5602
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using JNK3 antibody (CAB2112) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
