The JNK2 Polyclonal Antibody is a valuable tool for researchers studying the JNK2 protein, a member of the c-Jun N-terminal kinase (JNK) family involved in cell signaling pathways related to stress, inflammation, and apoptosis. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it suitable for Western blot applications.JNK2 is known for its role in regulating various cellular processes, including gene expression, cell proliferation, and cell death. Dysregulation of JNK2 signaling has been implicated in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions.
The JNK2 Polyclonal Antibody binds specifically to the JNK2 protein, allowing for the detection and analysis of its expression in different cell types.By studying the activity of JNK2, researchers can gain insights into its functions and potential therapeutic targets for related diseases. This antibody is a valuable tool for immunology and cancer research, providing a means to further understand the role of JNK2 in cellular physiology and pathophysiology.
Product Name:
JNK2 Polyclonal Antibody
SKU:
CAB1251
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-424 of human JNK2 (NP_002743.3).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
5601
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using JNK2 antibody (CAB1251) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
