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JNK1/JNK3 Monoclonal Antibody (CAB5051)

SKU:
CAB5051
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
$167 - $635
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:JNK1/JNK3 Monoclonal Antibody
SKU:CAB5051
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-383 of human JNK1 (P45983).This antibody does not cross react with JNK2 protein.
Sequence:MSRS KRDN NFYS VEIG DSTF TVLK RYQN LKPI GSGA QGIV CAAY DAIL ERNV AIKK LSRP FQNQ THAK RAYR ELVL MKCV NHKN IIGL LNVF TPQK SLEE FQDV YIVM ELMD ANLC QVIQ MELD HERM SYLL YQML CGIK HLHS AGII HRDL KPSN IVVK SDCT LKIL DFGL ARTA GTSF MMTP YVVT RYYR APEV ILGM GYKE NVDL WSVG CIMG EMVC HKIL FPGR DYID QWNK VIEQ LGTP CPEF MKKL QPTV RTYV ENRP KYAG YSFE KLFP DVLF PADS EHNK LKAS QARD LLSK MLVI DASK RISV DEAL QHPY INVW YDPS EAEA PPPK IPDK QLDE REHT IEEW KELI YKEV MDLE ERTK NGVI RGQP SPLG AAV
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; SAPK1; SAPK1c; JNK1/JNK3
Positive Sample:NIH/3T3,C6,Mouse heart
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:35kDa/44kDa/48kDa
Observed MW:40kDa/50kDa

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Purification Method:Affinity purification
Gene ID:5599/5602
Clone Number:ARC1163
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using JNK1/JNK3 Rabbit mAb (CAB5051) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1min.

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