JMY Antibody (PACO00989)
- SKU:
- PACO00989
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
JMY Antibody (PACO00989)
The JMY Polyclonal Antibody (PACO00989) is specifically designed for research involving JMY, a key regulator of cell migration and invasion in cancer progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding to the JMY protein, researchers can effectively detect and analyze its expression in different cell types, making it an essential tool for studies in cancer biology and metastasis.JMY, also known as junction-mediating and regulatory protein, plays a crucial role in promoting cell motility and tumor aggressiveness by enhancing the assembly of actin filaments and promoting cell migration.
Its involvement in cancer metastasis makes it a promising target for therapeutic interventions aimed at inhibiting tumor spread and improving patient outcomes. Investigating the function of JMY is essential for understanding the mechanisms driving cancer progression and identifying potential targets for anti-cancer therapies.
| Antibody Name: | JMY Antibody |
| Antibody SKU: | PACO00989 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | WB:1:500-1:2000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | synthesized peptide derived from the C-terminal region of human JMY. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | JMY; Junction-mediating and -regulatory protein |
| UniProt Protein Function: | JMY: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. Belongs to the JMY family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: leading edge; nucleoplasm; nucleus Molecular Function:protein binding; transcription coactivator activity Biological Process: cell cycle arrest; positive regulation of apoptosis; positive regulation of transcription factor activity; regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q8N9B5 |
| NCBI GenInfo Identifier: | 172045777 |
| NCBI Gene ID: | 133746 |
| NCBI Accession: | Q8N9B5.2 |
| UniProt Secondary Accession: | Q8N9B5,A1L4P5, B5MDS2, B5MDT0, |
| UniProt Related Accession: | Q8N9B5 |
| Molecular Weight: | 110,280 Da |
| NCBI Full Name: | Junction-mediating and -regulatory protein |
| NCBI Synonym Full Names: | junction mediating and regulatory protein, p53 cofactor |
| NCBI Official Symbol: | JMYÂ Â |
| NCBI Official Synonym Symbols: | WHAMM2; WHDC1L3Â Â |
| NCBI Protein Information: | junction-mediating and -regulatory protein |
| UniProt Protein Name: | Junction-mediating and -regulatory protein |
| Protein Family: | Junction-mediating and -regulatory protein |
| UniProt Gene Name: | JMYÂ Â |
| UniProt Entry Name: | JMY_HUMAN |
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