The Jarid1B Polyclonal Antibody (CAB14104) is a valuable tool for researchers studying Jarid1B, a key epigenetic regulator involved in gene expression and cell differentiation processes. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it an ideal choice for Western blot applications. By targeting the Jarid1B protein, this antibody enables precise detection and analysis in various cell types, providing insights into the role of Jarid1B in epigenetic regulation.Jarid1B, also known as KDM5B, is a histone demethylase that plays a crucial role in controlling gene expression by removing methyl groups from histone proteins.
Dysfunction of Jarid1B has been linked to various diseases, including cancer and developmental disorders. Understanding the function of Jarid1B is essential for unraveling its contribution to disease pathology and potential therapeutic interventions.Overall, the Jarid1B Polyclonal Antibody (CAB14104) serves as a valuable tool for researchers investigating the molecular mechanisms underlying gene regulation and cell differentiation processes, with implications for therapeutic development in cancer and other diseases.
Product Name:
JARID1B Rabbit Polyclonal Antibody
SKU:
CAB14104
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1400-1500 of human JARID1B (NP_006609.3).
This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10765
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of 293F, using JARID1B antibody (CAB14104) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
