The JAK3 Polyclonal Antibody (CAB0748) is a valuable tool for researchers studying Janus kinase 3 (JAK3), a critical enzyme involved in immune cell signaling. This antibody is produced in rabbits and is specifically reactive with human samples, making it ideal for use in Western blot applications. By binding to the JAK3 protein, this antibody enables precise detection and analysis in a variety of cell types, offering insights into the role of JAK3 in immunology and cancer research.JAK3 is a key player in immune system function, particularly in the development and activation of immune cells. Dysregulation of JAK3 signaling has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
Research on JAK3 is essential for understanding the mechanisms by which these diseases progress and for developing targeted therapies that can modulate immune responses effectively.Overall, the JAK3 Polyclonal Antibody (CAB0748) is a valuable resource for researchers seeking to delve into the intricate workings of JAK3 and its impact on immune system function and disease pathology. With its high specificity and reactivity, this antibody is a powerful tool for advancing our understanding of JAK3 biology and its implications for therapeutic interventions.
Product Name:
JAK3 Rabbit Polyclonal Antibody
SKU:
CAB0748
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-530 of JAK3 (NP_000206.2).
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).
Purification Method:
Affinity purification
Gene ID:
3718
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using JAK3 Rabbit pAb (CAB0748) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
