The JAK1 Rabbit Polyclonal Antibody (CAB5534) is a powerful tool for research in the field of immunology and cancer. This antibody targets JAK1, a key signaling molecule involved in immune responses and cell growth. Raised in rabbits, this antibody has been extensively validated for use in Western blot applications, offering high reactivity with human samples.JAK1 plays a crucial role in various cellular processes, including cytokine signaling and immune response regulation. Dysregulation of JAK1 signaling has been implicated in a variety of diseases, making it a promising target for therapeutic intervention.
By binding to JAK1 protein, this antibody enables precise detection and analysis in different cell types, providing valuable insights for studies on immune disorders, cancer biology, and drug development.With its high specificity and reliability, the JAK1 Rabbit Polyclonal Antibody (CAB5534) is an essential tool for researchers aiming to investigate the molecular mechanisms underlying immune regulation and disease pathogenesis. Its versatility and performance make it a valuable asset for advancing our understanding of JAK1 function in health and disease.
Product Name:
JAK1 Rabbit Polyclonal Antibody
SKU:
CAB5534
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human JAK1 (NP_002218.2).
Sequence:
VSEK KPAT EVDP THFE KRFL
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:
JTK3; AIIDE; JAK1A; JAK1B; JAK1
Positive Sample:
Mouse lung
Conjugate:
Unconjugated
Cellular Localization:
Endomembrane system, Peripheral membrane protein.
Calculated MW:
133kDa
Observed MW:
133kDa
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3716
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse lung, using JAK1 antibody (CAB5534) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
