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JAGN1 Antibody (PACO37938)

SKU:
PACO37938
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • JAGN1 Antibody PACO37938
  • JAGN1 Antibody PACO37938
  • JAGN1 Antibody PACO37938
€359

Description

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JAGN1 Antibody (PACO37938)

The JAGN1 Polyclonal Antibody (PAC037938) is ideal for researchers interested in studying JAGN1, a protein involved in immune regulation and cellular function. This antibody, derived from rabbit immunization, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding specifically to the JAGN1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable tool for studies in immunology and cancer research.

JAGN1, also known as Jagunal homolog 1, plays a critical role in cellular processes and immune system modulation. Understanding the function of JAGN1 is important for research into various diseases, including cancer, autoimmune disorders, and inflammatory conditions. By studying the activity of JAGN1, researchers can gain valuable insights that may contribute to the development of novel therapies targeting immune responses in disease settings.

Antibody Name:JAGN1 Antibody (PACO37938)
Antibody SKU:PACO37938
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Protein jagunal homolog 1 protein (1-39AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot. All lanes: JAGN1 antibody at 3µg/ml + HL60 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 22 kDa. Observed band size: 22 kDa.
Product ImageImmunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO37938 at dilution of 1:100.
Product ImageImmunohistochemistry of paraffin-embedded human colon cancer using PACO37938 at dilution of 1:100.
Background:Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
Synonyms:Protein jagunal homolog 1, JAGN1
UniProt Protein Function:JAGN1: May be required for endoplasmic reticulum organization. Belongs to the jagunal family.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 3p25.2Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membraneMolecular Function: protein bindingBiological Process: defense response to fungus; endoplasmic reticulum organization and biogenesis; exocytosis; neutrophil differentiation; neutrophil mediated immunity; protein transport; vesicle-mediated transportDisease: Neutropenia, Severe Congenital, 6, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a transmembrane protein. It functions in the early secretory pathway and is necessary for neutrophil differentiation and survival. Mutations in this gene result in severe congenital neutropenia. [provided by RefSeq, Oct 2014]
UniProt Code:Q8N5M9
NCBI GenInfo Identifier:190014601
NCBI Gene ID:84522
NCBI Accession:NP_115881
UniProt Secondary Accession:Q8N5M9,Q4KM64, Q5XKN4, Q2NKY9
UniProt Related Accession:Q8N5M9
Molecular Weight:
NCBI Full Name:protein jagunal homolog 1 isoform a
NCBI Synonym Full Names:jagunal homolog 1
NCBI Official Symbol:JAGN1  
NCBI Official Synonym Symbols:SCN6; GL009  
NCBI Protein Information:protein jagunal homolog 1
UniProt Protein Name:Protein jagunal homolog 1
UniProt Synonym Protein Names:
Protein Family:Protein jagunal
UniProt Gene Name:JAGN1  
UniProt Entry Name:JAGN1_HUMAN
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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