The JAG2 Polyclonal Antibody (CAB14247) is a vital tool for research involving JAG2, a key ligand in the Notch signaling pathway, which plays a crucial role in cell fate determination and tissue development. This antibody, generated using rabbits, shows high reactivity towards human samples and is validated for use in Western blot applications, allowing for the detection and analysis of JAG2 in various cell types. Its specificity and efficiency make it an essential component in studies related to developmental biology, cancer research, and regenerative medicine.JAG2 is a transmembrane protein known for its interactions with Notch receptors, leading to the activation of downstream signaling cascades that control cell differentiation, proliferation, and survival.
Understanding the function of JAG2 is imperative for uncovering its role in various physiological processes and pathological conditions, including cancer and developmental disorders. The JAG2 Polyclonal Antibody enables researchers to investigate the mechanisms underlying these complex biological processes and explore potential therapeutic targets for intervention.
Product Name:
JAG2 Rabbit Polyclonal Antibody
SKU:
CAB14247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-200 of human JAG2 (NP_002217.3).
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3714
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using JAG2 Rabbit pAb (CAB14247) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 20s.
