The JAG1 Polyclonal Antibody (CAB12754) is a valuable tool for research involving Jagged 1 (JAG1), a protein known for its role in the Notch signaling pathway, which plays a critical role in cell-cell communication and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the JAG1 protein, allowing for detection and analysis in various cell types, making it an ideal choice for studies in developmental biology and cancer research.
JAG1 is a key regulator of cell fate determination and differentiation, making it an important target for research into developmental disorders, cancer, and other diseases. By understanding the function of JAG1, researchers can gain insight into the mechanisms underlying these conditions and potentially identify new therapeutic targets. The JAG1 Polyclonal Antibody is a valuable tool for investigating the role of JAG1 in various biological processes and disease states.
Product Name:
JAG1 Rabbit Polyclonal Antibody
SKU:
CAB12754
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 34-180 of human JAG1 (NP_000205.1).
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter is involved in signaling processes. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
Purification Method:
Affinity purification
Gene ID:
182
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using JAG1 antibody (CAB12754) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
