The JAB1 Rabbit Monoclonal Antibody (CAB4087) is a vital tool for researchers studying the JAB1 protein, a key regulator of cell cycle progression and gene expression. This antibody, generated in rabbits, demonstrates high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications. By targeting the JAB1 protein, this antibody enables the detection and analysis of JAB1 in various cell types, facilitating research in areas such as cell biology, cancer, and drug development.
JAB1, also known as c-Jun activation domain-binding protein-1, is involved in regulating cell proliferation, apoptosis, and DNA repair processes. Dysregulation of JAB1 has been linked to various diseases, including cancer, making it a potential therapeutic target for drug discovery and treatment strategies. By studying the function and expression of JAB1, researchers can gain insights into its role in disease development and progression, leading to the identification of novel therapeutic interventions.
Product Name:
JAB1/CSN5/COPS5 Rabbit Monoclonal Antibody
SKU:
CAB4087
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human JAB1/CSN5/COPS5 (Q92905).
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Purification Method:
Affinity purification
Gene ID:
10987
Clone Number:
ARC0895
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using JAB1/CSN5/COPS5 Rabbit mAb (CAB4087) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
