JAB1/CSN5/COPS5 Rabbit Monoclonal Antibody (CAB4087)
- SKU:
- CAB4087
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | JAB1/CSN5/COPS5 Rabbit Monoclonal Antibody |
SKU: | CAB4087 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human JAB1/CSN5/COPS5 (Q92905). |
Sequence: | MAAS GSGM AQKT WELA NNMQ EAQS IDEI YKYD KKQQ QEIL AAKP WTKD HHYF KYCK ISAL ALLK MVMH ARSG GNLE VMGL MLGK VDGE TMII MDSF ALPV |
Tested Applications: | WB IHC-P IF/ICC ChIP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 ChIP,5μg antibody for 10μg-15μg of Chromatin |
Synonyms: | CSN5; JAB1; SGN5; MOV-34; JAB1/CSN5/COPS5 |
Positive Sample: | HeLa,293T,Mouse testis,Mouse kidney,Rat testis,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Cytoplasmic vesicle, Nucleus, perinuclear region, secretory vesicle, synaptic vesicle. |
Calculated MW: | 38kDa |
Observed MW: | 35kDa |
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
Purification Method: | Affinity purification |
Gene ID: | 10987 |
Clone Number: | ARC0895 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |