The ITPR3 Polyclonal Antibody (CAB12794) is a valuable tool for researchers studying the inositol 1,4,5-trisphosphate receptor type 3 (ITPR3), a key player in cellular signaling pathways. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blot applications. By targeting the ITPR3 protein, this antibody allows for precise detection and analysis in a variety of cell types, offering valuable insights into the role of ITPR3 in cellular function and signaling processes.ITPR3 is a critical component of calcium signaling pathways, playing a crucial role in regulating intracellular calcium levels and mediating various cellular processes such as cell growth, differentiation, and apoptosis.
Dysregulation of ITPR3 has been implicated in a variety of diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the function of ITPR3 and its involvement in these diseases is essential for the development of targeted therapies and interventions aimed at restoring healthy cellular signaling processes.Overall, the ITPR3 Polyclonal Antibody (CAB12794) offers researchers a reliable tool for investigating the complex role of ITPR3 in cellular signaling pathways and its implications in disease pathogenesis. Its high specificity and sensitivity make it a valuable asset for studies in molecular biology, cell biology, and disease research, paving the way for new insights and discoveries in the
Product Name:
ITPR3 Rabbit Polyclonal Antibody
SKU:
CAB12794
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1630-1870 of human ITPR3 (NP_002215.2).
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
Purification Method:
Affinity purification
Gene ID:
3710
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from HeLa cells, using ITPR3 Rabbit pAb (CAB12794) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
