The ITPR3 Monoclonal Antibody is a valuable tool for researchers studying the inositol trisphosphate receptor type 3 (ITPR3) protein, a key component in calcium signaling pathways. This antibody is designed for use in various research applications, including immunofluorescence, immunohistochemistry, and Western blotting, allowing for reliable detection and analysis of ITPR3 expression in cell and tissue samples.ITPR3 is known to play a crucial role in regulating calcium release from intracellular stores, which is essential for various cellular processes like cell proliferation, differentiation, and apoptosis.
Dysregulation of ITPR3 has been linked to several diseases, including cancer, neurological disorders, and cardiovascular diseases, making it a promising target for therapeutic intervention.By using the ITPR3 Monoclonal Antibody, researchers can gain valuable insights into the function and regulation of ITPR3 in different cellular contexts, advancing our understanding of its role in health and disease. Its high specificity and sensitivity make it a reliable tool for exploring the potential therapeutic implications of targeting ITPR3 in various pathological conditions.
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
Purification Method:
Affinity purification
Gene ID:
3710
Clone Number:
ARC59549
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using ITPR3 Rabbit mAb (CAB23202) at 1:5000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
