The ITPR1 Polyclonal Antibody (CAB7905) is a powerful tool for research in the field of neuroscience and cell signaling. This antibody specifically targets the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1), a key player in calcium signaling pathways within cells.Raised in rabbits, this antibody is known for its high reactivity with human samples, making it a reliable tool for Western blot applications. By binding to the ITPR1 protein, researchers are able to detect and analyze its expression in various cell types, providing valuable insights into its role in neuronal function and communication.ITPR1 is crucial for intracellular calcium release and modulation of synaptic transmission, making it a potential target for studies on neurodegenerative diseases, such as Alzheimer's and Parkinson's.
Understanding the function of ITPR1 can lead to the development of targeted therapies aimed at restoring calcium signaling balance in these conditions.Overall, the ITPR1 Polyclonal Antibody (CAB7905) offers researchers a valuable tool for investigating the role of ITPR1 in cellular signaling pathways, with potential implications for the development of novel therapeutic strategies in neurological disorders.
Product Name:
IP3R Rabbit Polyclonal Antibody
SKU:
CAB7905
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1812-1911 of human IP3R (XP_011531985.1).
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
3708
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using IP3R Rabbit pAb (CAB7905) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
