ITPKC Antibody (PACO21928)
- SKU:
- PACO21928
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ITPKC Antibody (PACO21928)
The ITPKC Polyclonal Antibody (PAC021928) is a valuable tool for researchers studying ITPKC, an important enzyme involved in immune regulation and calcium signaling pathways. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ITPKC protein, this antibody enables researchers to detect and analyze ITPKC expression in various cell types, making it ideal for studies in immunology and inflammation research.
ITPKC, also known as inositol-trisphosphate 3-kinase C, plays a crucial role in regulating immune responses and inflammation through its impact on calcium signaling pathways. Dysregulation of ITPKC has been implicated in various immune-related diseases, making it a promising target for therapeutic interventions. Understanding the function of ITPKC is essential for developing treatments for conditions such as autoimmune disorders, inflammatory diseases, and cancer that involve dysregulated immune responses.
| Antibody Name: | ITPKCµAntibody (PACO21928) |
| Antibody SKU: | PACO21928 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human IP3KC. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HT-29 cells, using IP3KC antibody. |
| Background: | Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. |
| Synonyms: | Inositol-trisphosphate 3-kinase C; EC 2.7.1.127; Inositol 1; 4; 5-trisphosphate 3-kinase C |
| UniProt Protein Function: | ITPKC: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. Defects in ITPKC are a cause of Kawasaki disease (KWD); also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self- limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries. Belongs to the inositol phosphokinase (IPK) family. |
| UniProt Protein Details: | Protein type:Kinase, lipid; EC 2.7.1.127; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: cytosol; nucleoplasm Molecular Function:inositol trisphosphate 3-kinase activity Biological Process: inositol phosphate metabolic process; positive regulation of defense response to virus by host Disease: Kawasaki Disease |
| NCBI Summary: | This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009] |
| UniProt Code: | Q96DU7 |
| NCBI GenInfo Identifier: | 74731499 |
| NCBI Gene ID: | 80271 |
| NCBI Accession: | Q96DU7.1 |
| UniProt Secondary Accession: | Q96DU7,Q9UE25, Q9Y475, |
| UniProt Related Accession: | Q96DU7 |
| Molecular Weight: | 75,207 Da |
| NCBI Full Name: | Inositol-trisphosphate 3-kinase C |
| NCBI Synonym Full Names: | inositol-trisphosphate 3-kinase C |
| NCBI Official Symbol: | ITPKCÂ Â |
| NCBI Official Synonym Symbols: | IP3KC; IP3-3KCÂ Â |
| NCBI Protein Information: | inositol-trisphosphate 3-kinase C |
| UniProt Protein Name: | Inositol-trisphosphate 3-kinase C |
| UniProt Synonym Protein Names: | Inositol 1,4,5-trisphosphate 3-kinase C; IP3 3-kinase C; IP3K C; InsP 3-kinase C |
| Protein Family: | Inositol-trisphosphate 3-kinase |
| UniProt Gene Name: | ITPKCÂ Â |
| UniProt Entry Name: | IP3KC_HUMAN |
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