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ITPKC Antibody (PACO10020)

SKU:
PACO10020
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
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Description

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ITPKC Antibody (PACO10020)

The ITPKC Antibody (PACO10020) is a high-quality antibody designed for research involving ITPKC, a key protein involved in immune regulation and calcium signaling pathways. This polyclonal antibody, raised in rabbits, is specifically targeted towards detecting ITPKC in human samples and is validated for use in various applications, including Western blotting.ITPKC, also known as inositol-trisphosphate 3-kinase C, plays a crucial role in regulating T cell activation and cytokine production, making it a valuable target for studies in immunology and inflammatory diseases. By targeting ITPKC, researchers can gain insights into the mechanisms underlying immune responses and potentially identify new therapeutic targets for diseases such as autoimmune disorders and inflammatory conditions.

With its high reactivity and specificity for human ITPKC, the PACO10020 Antibody is a powerful tool for researchers looking to explore the role of ITPKC in immune signaling pathways and its potential implications for human health. Whether studying immune responses in cancer, autoimmune diseases, or other inflammatory conditions, this antibody provides a reliable and versatile option for detecting and analyzing ITPKC expression in various cell types.

Antibody Name:ITPKC Antibody (PACO10020)
Antibody SKU:PACO10020
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IF
Recommended Dilutions:
Species Reactivity:Human
Immunogen:Human ITPKC
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:inositol 1,4,5-trisphosphate 3-kinase C;ITPKC;IP3KC ;
UniProt Protein Function:ITPKC: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate. Defects in ITPKC are a cause of Kawasaki disease (KWD); also known as mucocutaneous lymph node syndrome or infantile polyarteritis. Kawasaki disease is an acute, self- limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy. Coronary artery aneurysms develop in 15 to 25% of those left untreated, making Kawasaki disease the leading cause of acquired heart disease among children in developed countries. Belongs to the inositol phosphokinase (IPK) family.
UniProt Protein Details:

Protein type:Kinase, lipid; EC 2.7.1.127; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: cytosol; nucleoplasm

Molecular Function:inositol trisphosphate 3-kinase activity

Biological Process: inositol phosphate metabolic process; positive regulation of defense response to virus by host

Disease: Kawasaki Disease

NCBI Summary:This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
UniProt Code:Q96DU7
NCBI GenInfo Identifier:74731499
NCBI Gene ID:80271
NCBI Accession:Q96DU7.1
UniProt Secondary Accession:Q96DU7,Q9UE25, Q9Y475,
UniProt Related Accession:Q96DU7
Molecular Weight:75,207 Da
NCBI Full Name:Inositol-trisphosphate 3-kinase C
NCBI Synonym Full Names:inositol-trisphosphate 3-kinase C
NCBI Official Symbol:ITPKC  
NCBI Official Synonym Symbols:IP3KC; IP3-3KC  
NCBI Protein Information:inositol-trisphosphate 3-kinase C
UniProt Protein Name:Inositol-trisphosphate 3-kinase C
UniProt Synonym Protein Names:Inositol 1,4,5-trisphosphate 3-kinase C; IP3 3-kinase C; IP3K C; InsP 3-kinase C
Protein Family:Inositol-trisphosphate 3-kinase
UniProt Gene Name:ITPKC  
UniProt Entry Name:IP3KC_HUMAN

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