The ITPKA Polyclonal Antibody (CAB17503) is a valuable tool for researchers studying the protein ITPKA, an enzyme involved in calcium-mediated signal transduction pathways. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. It binds specifically to the ITPKA protein, allowing for accurate detection and analysis in a variety of cell types.ITPKA is known to play a critical role in regulating cellular processes such as cell proliferation, differentiation, and apoptosis. Dysregulation of ITPKA has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic conditions.
By studying the function and expression of ITPKA, researchers can gain valuable insights into these disease mechanisms and potentially identify new therapeutic targets.With its high specificity and sensitivity, the ITPKA Polyclonal Antibody is a valuable tool for research in molecular biology, biochemistry, and cell signaling. Its ability to accurately detect and quantify ITPKA protein levels makes it an essential reagent for studies aimed at elucidating the role of ITPKA in health and disease.
Product Name:
ITPKA Rabbit Polyclonal Antibody
SKU:
CAB17503
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 141-461 of human ITPKA (NP_002211.1).
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.
Purification Method:
Affinity purification
Gene ID:
3706
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ITPKA Rabbit pAb (CAB17503) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
