ITPKA Rabbit Polyclonal Antibody (CAB17503)
- SKU:
- CAB17503
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | ITPKA Rabbit Polyclonal Antibody |
SKU: | CAB17503 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 141-461 of human ITPKA (NP_002211.1). |
Sequence: | LLSD SESR SRGN VQLE AGED VGQK NHWQ KIRT MVNL PVIS PFKK RYAW VQLA GHTG SFKA AGTS GLIL KRCS EPER YCLA RLMA DALR GCVP AFHG VVER DGES YLQL QDLL DGFD GPCV LDCK MGVR TYLE EELT KARE RPKL RKDM YKKM LAVD PEAP TEEE HAQR AVTK PRYM QWRE GISS STTL GFRI EGIK KADG SCST DFKT TRSR EQVL RVFE EFVQ GDEE VLRR YLNR LQQI RDTL EVSE FFRR HEVI GSSL LFVH DHCH RAGV WLID FGKT TPLP DGQI LDHR RPWE EGNR EDGY LLGL DNLI GILA SLAE R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | IP3KA; IP3-3KA; ITPKA |
Positive Sample: | Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytoskeleton, cytosol, dendritic spine, glutamatergic synapse, nucleus, postsynaptic actin cytoskeleton |
Calculated MW: | 51kDa |
Observed MW: | 55kDa |
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.
Purification Method: | Affinity purification |
Gene ID: | 3706 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |