The ITGB3BP Polyclonal Antibody (CAB5839) is a valuable tool for researchers studying the ITGB3BP protein, also known as Integrin Beta-3 Binding Protein. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications.ITGB3BP is a protein that interacts with integrin beta-3 and is involved in cell adhesion and migration processes. Research has shown that ITGB3BP plays a role in various cellular functions, including cell signaling and proliferation. By using the CAB5839 antibody, researchers can detect and analyze ITGB3BP protein levels in different cell types, providing insights into its functions and potential implications in disease.Studies have implicated ITGB3BP in cancer progression, angiogenesis, and metastasis, making it a promising target for cancer research.
Additionally, ITGB3BP has been linked to cardiovascular diseases and inflammatory conditions, highlighting its importance in various pathological processes. By understanding the role of ITGB3BP, researchers can potentially develop new therapeutic approaches for these diseases.In conclusion, the ITGB3BP Polyclonal Antibody is a reliable tool for investigating the functions and mechanisms of ITGB3BP in various biological contexts. Its specificity and sensitivity make it suitable for a wide range of research applications, including cancer biology, cardiovascular research, and inflammatory disorders.
Product Name:
ITGB3BP Rabbit Polyclonal Antibody
SKU:
CAB5839
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-111 of human ITGB3BP (NP_055103.3).
This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
23421
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Mouse liver, using ITGB3BP Rabbit pAb (CAB5839) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
