The ITGAL Polyclonal Antibody (CAB16903) is a valuable tool for research involving ITGAL, also known as integrin alpha L, a cell surface molecule involved in immune cell adhesion and migration. This rabbit-derived antibody is highly specific to human samples and is validated for use in applications such as Western blotting. By binding to the ITGAL protein, this antibody enables the detection and analysis of ITGAL in various cell types, making it ideal for studies in immunology and cancer research.ITGAL plays a crucial role in immune response regulation by mediating the adhesion of leukocytes to endothelial cells during the inflammatory response.
Its involvement in leukocyte trafficking and migration makes ITGAL a key player in immune system function and inflammatory processes. Research into ITGAL function is important for understanding how immune cells interact with and respond to their environment, providing insights into diseases such as cancer, autoimmune disorders, and inflammatory conditions.Overall, the ITGAL Polyclonal Antibody is a valuable tool for researchers studying the role of ITGAL in immune cell function and immune response modulation, with potential implications for the development of therapies targeting immune-related diseases.
Product Name:
CD11a/LFA-1A/ITGAL Rabbit Polyclonal Antibody
SKU:
CAB16903
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 26-306 of human CD11a/LFA-1A/CD11a/LFA-1A/ITGAL (NP_001107852.1).
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3683
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD11a/LFA-1A/CD11a/LFA-1A/ITGAL Rabbit pAb (CAB16903) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
