The Integrin Alpha-E Polyclonal Antibody (CAB9934) is a key tool for researchers studying integrin alpha-E, a cell adhesion molecule that plays a critical role in immune responses and inflammatory processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Integrin alpha-E is involved in the regulation of cell adhesion and migration, making it a key player in processes such as immune cell trafficking and tissue inflammation. Its expression patterns have been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.
By targeting integrin alpha-E, researchers can gain valuable insights into the roles of this molecule in disease pathogenesis and potentially identify new therapeutic targets.This polyclonal antibody binds specifically to integrin alpha-E, enabling accurate detection and analysis in a variety of cell types. Its versatile applications make it an ideal tool for research in immunology, cancer biology, and inflammation-related studies. Overall, the Integrin Alpha-E Polyclonal Antibody (CAB9934) is essential for advancing our understanding of integrin alpha-E biology and its implications in disease progression.
Product Name:
ITGAE Rabbit Polyclonal Antibody
SKU:
CAB9934
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 19-200 of human ITGAE (NP_002199.3).
Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
Purification Method:
Affinity purification
Gene ID:
3682
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ITGAE antibody (CAB9934) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
