The ITGA8 Polyclonal Antibody (CAB13056) is a valuable tool for researchers studying integrin alpha 8 (ITGA8), a cell surface receptor involved in cell adhesion and migration processes. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ITGA8 protein, this antibody enables researchers to detect and analyze ITGA8 expression in various cell types, making it ideal for studies in cell biology, developmental biology, and cancer research.ITGA8 is known for its role in mediating cell-to-cell and cell-to-extracellular matrix interactions, contributing to pathways involved in tissue development, wound healing, and tumor progression.
Understanding the function of ITGA8 is crucial for unraveling its involvement in physiological processes and diseases such as fibrosis, cancer metastasis, and vascular disorders. The ITGA8 Polyclonal Antibody provides researchers with a valuable tool to explore the role of ITGA8 in these contexts and discover potential therapeutic targets for related conditions.
Product Name:
ITGA8 Rabbit Polyclonal Antibody
SKU:
CAB13056
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 907-1000 of human ITGA8 (NP_003629.2).
Cell membrane, Membrane, Single-pass type I membrane protein.
Calculated MW:
117kDa
Observed MW:
117kDa
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
8516
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ITGA8 Rabbit pAb (CAB13056) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
