The ITGA1 Polyclonal Antibody (CAB16054) is a valuable tool for researchers studying integrin alpha-1 (ITGA1), a cell surface receptor involved in cell adhesion and signaling pathways. This rabbit-derived antibody is highly reactive with human samples and has been validated for use in Western blot applications. By specifically binding to the ITGA1 protein, this antibody enables detection and analysis in a variety of cell types, making it ideal for investigations in cell biology, developmental biology, and cancer research.
ITGA1 is known to play a crucial role in cell adhesion to collagen and laminin, important components of the extracellular matrix. Dysregulation of ITGA1 has been implicated in various diseases, including cancer metastasis, fibrosis, and developmental disorders. By studying the function of ITGA1 using this antibody, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
ITGA1 Rabbit Polyclonal Antibody
SKU:
CAB16054
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ITGA1 (NP_852478.1).
This gene encodes the alpha 1 subunit of integrin receptors. This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. The heterodimeric receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding.
Purification Method:
Affinity purification
Gene ID:
3672
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ITGA1 Rabbit pAb (CAB16054) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
