[KO Validated] ITCH Rabbit Polyclonal Antibody (CAB15612)
- SKU:
- CAB15612
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | [KO Validated] ITCH Rabbit Polyclonal Antibody |
SKU: | CAB15612 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of ITCH (NP_001244066.1). |
Sequence: | MSDS GSQL GSMG SLTM KSQL QITV ISAK LKEN KKNW FGPS PYVE VTVD GQSK KTEK CNNT NSPK WKQP LTVI VTPV SKLH FRVW SHQT LKSD VLLG TAAL DIYE TLKS NNMK LEEV VVTL QLGG DKEP TETI GDLS ICLD GLQL ESEV VTNG ETT |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | AIF4; AIP4; ADMFD; NAPP1; CH |
Positive Sample: | 293T,THP-1,NIH/3T3,C6,Mouse lung,Mouse kidney,Rat lung,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | cell cortex, cytoplasm, cytoplasmic vesicle, cytosol, extracellular exosome, nucleoplasm, plasma membrane |
Calculated MW: | 103kDa |
Observed MW: | 103kDa |
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method: | Affinity purification |
Gene ID: | 83737 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |