The Islet1 Rabbit Monoclonal Antibody is a highly specific and sensitive tool for researching Islet1, a critical transcription factor involved in the development and function of pancreatic islet cells. This antibody, produced in rabbits, is perfectly suited for various applications including immunofluorescence, immunohistochemistry, and flow cytometry.Islet1, also known as Isl-1, plays a pivotal role in the regulation of pancreatic development and the differentiation of insulin-producing beta cells. It is essential for proper insulin secretion and glucose homeostasis, making it a key target for studies in diabetes research and regenerative medicine.
This antibody recognizes Islet1 with high affinity and specificity, allowing for precise detection and analysis of Islet1 expression in various cell types and tissues. Its versatility and reliability make it an indispensable tool for investigating the role of Islet1 in pancreatic development, diabetes pathogenesis, and potential therapeutic interventions.
Product Name:
Islet1 Rabbit Monoclonal Antibody
SKU:
CAB0871
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Islet1 (P61371).
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young.
Purification Method:
Affinity purification
Gene ID:
3670
Clone Number:
ARC0511
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Islet1 Rabbit mAb (CAB0871) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
