ISL2 Antibody (PACO00987)
- SKU:
- PACO00987
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ISL2 Antibody (PACO00987)
The ISL2 Polyclonal Antibody (PACO00987) is a valuable tool for researchers studying ISL2, a transcription factor essential for the development of motor neurons and pancreas. This antibody, produced in vitro, is highly specific for ISL2 in human samples and has been validated for use in immunofluorescence and immunohistochemistry applications. By binding to the ISL2 protein, this antibody enables precise detection and localization of ISL2 in various cell types, allowing for detailed analysis in developmental biology and neurology research.
ISL2, also known as insulin gene enhancer protein ISL-2, plays a crucial role in the differentiation and function of motor neurons and pancreatic beta cells. Its function in regulating gene expression makes it a key player in neural development and glucose metabolism. Research into ISL2 is critical for understanding neural circuitry formation, motor neuron diseases, and diabetes mellitus. By studying ISL2 expression and function, researchers can potentially uncover new therapeutic targets for neurological disorders and diabetes.
| Antibody Name: | ISL2 Antibody |
| Antibody SKU: | PACO00987 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | WB:1:500-1:2000, IF:1:200-1:1000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the Internal region of human Islet-2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | ISL2; Insulin gene enhancer protein ISL-2; Islet-2 |
| UniProt Protein Function: | islet-2: Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 15q23 Cellular Component: nucleus Molecular Function:DNA binding; sequence-specific DNA binding; zinc ion binding Biological Process: negative regulation of neuron differentiation; neuron development; peripheral nervous system neuron development; regulation of transcription, DNA-dependent; retinal ganglion cell axon guidance; spinal cord motor neuron cell fate specification; visceral motor neuron differentiation |
| UniProt Code: | Q96A47 |
| NCBI GenInfo Identifier: | 20978495 |
| NCBI Gene ID: | 64843 |
| NCBI Accession: | Q96A47.1 |
| UniProt Secondary Accession: | Q96A47,B3KM37, |
| UniProt Related Accession: | Q96A47 |
| Molecular Weight: | 39,768 Da |
| NCBI Full Name: | Insulin gene enhancer protein ISL-2 |
| NCBI Synonym Full Names: | ISL LIM homeobox 2 |
| NCBI Official Symbol: | ISL2Â Â |
| NCBI Protein Information: | insulin gene enhancer protein ISL-2 |
| UniProt Protein Name: | Insulin gene enhancer protein ISL-2 |
| Protein Family: | Insulin gene enhancer protein |
| UniProt Gene Name: | ISL2Â Â |
| UniProt Entry Name: | ISL2_HUMAN |
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