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ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)

SKU:
CPAB0518
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
P3E5AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

ISG15 Monoclonal Antibody [P3E5AT] (CPAB0518)

The ISG15 Polyclonal Antibody (CPAB0518) is a valuable tool for researchers studying ISG15, an interferon-induced protein known for its role in antiviral and immune responses. This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it a reliable option for Western blot applications. By binding to the ISG15 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in virology, immunology, and infectious disease research.

ISG15, also referred to as interferon-stimulated gene 15, plays a crucial role in the innate immune response by regulating the activity of various proteins involved in antiviral defense. Its involvement in immune signaling pathways makes it a promising target for studying viral infections, immune system activation, and inflammatory processes. Research into the functions of ISG15 is essential for advancing our understanding of host immune responses and developing strategies to combat viral infections and autoimmune diseases.

Product Name:ISG15 Antibody
Product Sku:CPAB0518
Size:5μg
Host Species:Mouse
Immunogen:Anti-human ISG15 mAb is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with recombinant human ISG15 amino acids 1-157 purified from Ecoli.
Clone:P3E5AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:ISG15 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:ISG15 ubiquitin-like Modifier is conjugated to the intracellular target proteins after IFN-alpha or IFN-beta stimulation. ISG15 enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the ub conjugation pathway at the level of a specific E2 enzyme. ISG15 protein targets include STAT1, SERPINA 3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MXA, and RIG-1. Deconjugated by USP18/UBP43 shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. ISG15 serves as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments. ISG15 plays a role in autocrine, paracrine and endocrine mechanisms, as in cell-to-cell signaling, possibly partly by inducing ifn-gamma secretion by monocytes and macrophages. ISG15 displays a
Synonyms:ISG15, G1P2, IFI15, UCRP, Interferon-induced 17 kDa protein precursor, ISG15 Ubiquitin-like modifier.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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