The ISCA2 Polyclonal Antibody (PAC037290) is a valuable tool for researchers studying ISCA2, a protein involved in iron-sulfur cluster assembly. The antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting ISCA2 in human samples, making it ideal for Western blot applications. By targeting the ISCA2 protein, researchers can gain insights into its role in cellular processes related to iron metabolism and mitochondrial function.ISCA2 is a key player in the biogenesis of iron-sulfur clusters, essential cofactors for numerous proteins involved in electron transfer and redox reactions.
Dysregulation of ISCA2 has been linked to various disorders, including mitochondrial diseases and sideroblastic anemia. By investigating the function of ISCA2, researchers can uncover potential therapeutic targets for treating these conditions and further advance our understanding of cellular iron homeostasis.Overall, the ISCA2 Polyclonal Antibody is a valuable tool for researchers interested in exploring the role of ISCA2 in iron metabolism and mitochondrial biology. Its high reactivity and specificity make it a reliable choice for studying the functions of ISCA2 in various biological contexts.
Western blot. All lanes: ISCA2 antibody at 0.4µg/ml + HL60 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 17, 7 kDa. Observed band size: 17 kDa.
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO37290 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human prostate cancer using PACO37290 at dilution of 1:100.
Background:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly.
ISCA2: Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly. Belongs to the HesB/IscA family.Chromosomal Location of Human Ortholog: 14q24.3Cellular Component: mitochondrial matrixMolecular Function: 2 iron, 2 sulfur cluster binding; 4 iron, 4 sulfur cluster binding; ferrous iron binding; protein binding; structural molecule activityBiological Process: iron-sulfur cluster assembly; sulfur metabolic processDisease: Multiple Mitochondrial Dysfunctions Syndrome 4
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an A-type iron-sulfur cluster (ISC) protein found in mitochondria. The encoded protein appears to be involved in the maturation of mitochondrial iron-sulfur proteins. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
