The ISCA1 Polyclonal Antibody (PAC051134) is a valuable tool for researchers studying the ISCA1 protein, a key player in iron-sulfur cluster assembly. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ISCA1 protein, this antibody enables researchers to detect and analyze ISCA1 levels in a variety of cell types, making it an ideal choice for studies focused on biochemistry and mitochondria function.
ISCA1 is essential for the biosynthesis of iron-sulfur clusters, critical cofactors in a wide range of cellular processes including respiration, DNA repair, and amino acid biosynthesis. Dysregulation of ISCA1 has been linked to various human diseases, including mitochondrial disorders and neurodegenerative conditions. By studying the function of ISCA1, researchers can gain insight into the mechanisms underlying these diseases and potentially develop targeted therapies to address them.
Antibody Name:
ISCA1 Antibody (PACO51134)
Antibody SKU:
PACO51134
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Iron-sulfur cluster assembly 1 homolog, mitochondrial protein (67-122AA)
Immunohistochemistry of paraffin-embedded human liver tissue using PACO51134 at dilution of 1:100.
Background:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
Synonyms:
Iron-sulfur cluster assembly 1 homolog, mitochondrial (HESB-like domain-containing protein 2) (Iron-sulfur assembly protein IscA) (hIscA), ISCA1, HBLD2
UniProt Protein Function:
Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly.
UniProt Protein Details:
NCBI Summary:
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008]
