The IRX6 Antibody (PACO59756) is a vital tool for researchers studying IRX6, a transcription factor involved in heart development and angiogenesis. This polyclonal antibody, produced in rabbits, is highly specific for IRX6 and has been validated for use in immunohistochemistry and Western blotting applications. It allows for the detection and analysis of IRX6 protein expression in a variety of biological samples, making it an essential tool for cardiovascular and developmental biology research.IRX6 is known to play a crucial role in heart development, specifically in the formation of cardiac chambers and the regulation of gene expression during embryonic development.
Its function in angiogenesis also makes it a potential target for studying vascular development and diseases related to abnormal blood vessel formation. By understanding the role of IRX6 in these processes, researchers may uncover new insights into heart disease and vascular disorders, leading to potential therapeutic advancements.
Western Blot. Positive WB detected in: A549 whole cell lysate, Rat heart tissue. All lanes: IRX6 antibody at 3.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 49 kDa. Observed band size: 49 kDa.
IHC image of PACO59756 diluted at 1:200 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Synonyms:
Iroquois-class homeodomain protein IRX-6 (Homeodomain protein IRXB3) (Iroquois homeobox protein 6), IRX6, IRX7 IRXB3
UniProt Protein Function:
IRX6: Belongs to the TALE/IRO homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 16q12.2
