The IRS2 Polyclonal Antibody (CAB7945) is a valuable tool for research involving the insulin receptor substrate 2 (IRS2), a key player in insulin signaling pathways. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the IRS2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in diabetes, metabolic disorders, and cancer research.
IRS2 is a critical mediator in insulin signaling, playing a crucial role in the regulation of glucose metabolism, cell growth, and survival. Dysregulation of IRS2 has been implicated in various metabolic disorders, making it an important target for further research into diabetes, obesity, and other related conditions. Understanding the functions and pathways associated with IRS2 is essential for developing targeted therapies and treatments aimed at improving metabolic health and addressing related diseases.
Product Name:
IRS2 Rabbit Polyclonal Antibody
SKU:
CAB7945
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1238-1338 of human IRS2 (NP_003740.2).
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.
Purification Method:
Affinity purification
Gene ID:
8660
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using IRS2 Rabbit pAb (CAB7945) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
