The IRS1 Rabbit Monoclonal Antibody (CAB19074) is a high-quality antibody designed for research involving Insulin Receptor Substrate 1 (IRS1), a key mediator of insulin signaling pathways. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for Western blot applications. IRS1 plays a crucial role in regulating glucose metabolism, cell growth, and survival, making it a significant target for studies in metabolic disorders such as diabetes and cancer. By binding to the IRS1 protein, this antibody enables precise detection and analysis in a variety of cell types, allowing for in-depth research in the fields of endocrinology and oncology.
Understanding the function and regulation of IRS1 is essential for developing new therapeutic strategies for diseases associated with insulin resistance and dysregulated cell growth. By utilizing the IRS1 Rabbit Monoclonal Antibody, researchers can further explore the complexities of insulin signaling pathways and potential treatment options for related conditions.
Product Name:
IRS1 Rabbit Monoclonal Antibody
SKU:
CAB19074
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1100-1200 of human IRS1 (P35568).
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Purification Method:
Affinity purification
Gene ID:
3667
Clone Number:
ARC0486
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HepG2 cells, using IRS1 antibody (CAB19074) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
