The IRS1 Polyclonal Antibody (CAB16902) is a valuable tool for researchers studying the insulin receptor substrate 1 (IRS1) protein, a key player in insulin signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the IRS1 protein, this antibody enables the accurate detection and analysis of IRS1 expression in various cell types, making it an essential component for studies in diabetes, metabolic disorders, and other related fields.
IRS1 is a crucial mediator of insulin signaling, playing a central role in glucose metabolism, cell growth, and differentiation. Dysregulation of IRS1 function is associated with insulin resistance, a hallmark of type 2 diabetes and other metabolic diseases. By understanding the role of IRS1 in these conditions, researchers can pave the way for the development of novel therapeutic strategies aimed at improving insulin sensitivity and metabolic health.
Product Name:
IRS1 Rabbit Polyclonal Antibody
SKU:
CAB16902
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1043-1242 of human IRS1 (NP_005535.1).
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Purification Method:
Affinity purification
Gene ID:
3667
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using IRS1 Rabbit pAb (CAB16902) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
