The IRS1 Polyclonal Antibody (CAB0245) is a valuable tool for researchers studying Insulin Receptor Substrate 1 (IRS1), a key player in insulin signaling and metabolism. Raised in rabbits, this antibody is highly specific for human samples and is validated for use in Western blot applications. By binding to the IRS1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for research in diabetes, obesity, and other metabolic disorders.
IRS1 is a critical mediator of insulin signaling, playing a key role in glucose uptake, glycogen synthesis, and lipid metabolism. Dysregulation of IRS1 is associated with insulin resistance, a hallmark of type 2 diabetes, as well as other metabolic diseases. By understanding the function and regulation of IRS1, researchers can gain insight into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
IRS1 Rabbit Polyclonal Antibody
SKU:
CAB0245
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1043-1242 of human IRS1 (NP_005535.1).
This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.
Purification Method:
Affinity purification
Gene ID:
3667
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using IRS1 Rabbit pAb (CAB0245) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
