The IRF8 Polyclonal Antibody (CAB13677) is a valuable tool for researchers studying the IRF8 protein, a transcription factor involved in immune response regulation. This antibody is produced in rabbits and demonstrates high reactivity with human samples, making it suitable for use in Western blotting applications. By specifically binding to the IRF8 protein, this antibody enables precise detection and analysis in various cell types, providing insights into the role of IRF8 in immunology and cancer research.IRF8 is known to play a critical role in the regulation of immune responses, particularly in the development and function of immune cells such as dendritic cells and macrophages.
Dysregulation of IRF8 has been implicated in various diseases, including autoimmune disorders, infectious diseases, and cancer. By studying the expression and function of IRF8 with this antibody, researchers can gain a better understanding of its implications in disease pathogenesis and potentially identify new therapeutic targets for intervention.
Product Name:
IRF8 Rabbit Polyclonal Antibody
SKU:
CAB13677
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 137-426 of human IRF8 (NP_002154.1).
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.
Purification Method:
Affinity purification
Gene ID:
3394
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from HL-60 cells, using IRF8 Rabbit pAb (CAB13677) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
