Applying the same template to the provided URL:The IRF6 Polyclonal Antibody (CAB6246) is a valuable tool for researchers studying the transcription factor IRF6, known for its role in craniofacial and epidermal development. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. By binding to the IRF6 protein, it allows for accurate detection and analysis in a variety of cell types, making it a crucial asset for studies in developmental biology and genetics.
IRF6 is a key regulator of epithelial development and immune response, making it a focal point in research related to congenital anomalies and inflammatory disorders. Understanding the function of IRF6 is essential for unraveling the mechanisms underlying these conditions and identifying potential therapeutic targets. By using the IRF6 Polyclonal Antibody, researchers can gain valuable insights into the molecular pathways controlled by IRF6, driving advancements in personalized medicine and treatment strategies.
Product Name:
IRF6 Rabbit Polyclonal Antibody
SKU:
CAB6246
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 115-300 of human IRF6 (NP_006138.1).
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3664
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IRF6 antibody (CAB6246) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 15s.
