The Anti-IRF6 Polyclonal Antibody (CAB3209) is a valuable tool for researchers studying IRF6, a transcription factor that plays a key role in the development of epithelial tissues, specifically in the formation of skin, oral mucosa, and other organs. This antibody, generated in rabbits, is highly specific to human IRF6 samples and has been validated for use in Western blot applications.IRF6 is essential for proper cell differentiation and proliferation, making it a crucial regulator of tissue development and repair. Dysregulation of IRF6 has been linked to a variety of developmental disorders, including orofacial clefts and skin abnormalities.
By targeting IRF6 with this antibody, researchers can study its expression and function in various cell types, providing insights into its role in embryonic development and disease pathology.With its high specificity and sensitivity, the Anti-IRF6 Polyclonal Antibody enables detection and analysis of IRF6 protein levels in both normal and diseased tissues, making it a valuable tool for investigations in developmental biology, dermatology, and genetic disorders. Understanding the function of IRF6 is essential for advancing knowledge of tissue development and identifying potential therapeutic targets for related conditions.
Product Name:
IRF6 Rabbit Monoclonal Antibody
SKU:
CAB3209
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 368-467 of human IRF6 (O14896).
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
3664
Clone Number:
ARC1928
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using IRF6 Rabbit mAb (CAB3209) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
