The IRF5 Polyclonal Antibody (CAB16388) is a valuable tool for researching the IRF5 protein, a transcription factor involved in the regulation of immune responses. This antibody, produced in rabbits, is specifically designed to target human samples and has been validated for use in Western blot applications. By binding to the IRF5 protein, the antibody allows for accurate detection and analysis in various cell types, making it an essential asset for studies in immunology and inflammatory conditions.IRF5 plays a critical role in the activation of immune responses, including the production of pro-inflammatory cytokines and the regulation of inflammatory pathways.
Dysregulation of IRF5 activity has been linked to autoimmune diseases, chronic inflammation, and cancer, making it a promising target for therapeutic interventions. By studying the role of IRF5 in immune regulation, researchers can gain valuable insights into the underlying mechanisms of these diseases and potentially identify new treatment strategies.Overall, the IRF5 Polyclonal Antibody (CAB16388) is a high-quality reagent that enables precise detection and analysis of IRF5 protein levels in human samples. Its reliability and specificity make it a valuable tool for advancing our understanding of immune regulation and disease pathogenesis.
Product Name:
IRF5 Rabbit Polyclonal Antibody
SKU:
CAB16388
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human IRF5 (NP_001092097.2).
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
Purification Method:
Affinity purification
Gene ID:
3663
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using IRF5 Rabbit pAb (CAB16388) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
