The IRF5 Polyclonal Antibody (CAB1149) is a powerful tool for researchers studying the immune system and inflammatory responses. This antibody, raised in rabbits, specifically targets the IRF5 protein, a key player in the regulation of immune responses and the inflammatory process. Validated for use in Western blot applications, the IRF5 Polyclonal Antibody is highly reactive with human samples, making it an essential tool for studies in immunology and autoimmune diseases.IRF5, also known as interferon regulatory factor 5, is a transcription factor that plays a crucial role in the activation of immune responses and the production of pro-inflammatory cytokines. Dysregulation of IRF5 has been implicated in various autoimmune disorders, making it a promising target for drug development and precision medicine approaches.
By targeting IRF5 with this antibody, researchers can gain valuable insights into its function and potential therapeutic applications in conditions such as lupus, rheumatoid arthritis, and inflammatory bowel disease.Overall, the IRF5 Polyclonal Antibody (CAB1149) is a versatile tool for investigating the role of IRF5 in immune regulation and inflammatory diseases. Its high specificity and reactivity make it an indispensable resource for researchers seeking to better understand the molecular mechanisms underlying immune responses and develop targeted therapies for immune-related disorders.
Product Name:
IRF5 Rabbit Polyclonal Antibody
SKU:
CAB1149
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human IRF5 (NP_001092097.2).
This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment.
Purification Method:
Affinity purification
Gene ID:
3663
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IRF5 antibody (CAB1149) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
