The IRF4 Polyclonal Antibody (CAB1052) is a valuable tool for research involving the transcription factor IRF4, a critical regulator of immune cell development and function. The antibody, produced in rabbits, is highly specific for human samples and has been optimized for use in Western blot applications. By binding to IRF4, this antibody enables the detection and analysis of the protein in various cell types, making it ideal for studies in immunology and cancer research.
IRF4 is known for its role in promoting the differentiation and function of T cells, B cells, and dendritic cells, making it a key player in the immune response. Its dysregulation has been linked to various immune disorders, including autoimmune diseases and lymphomas. By studying IRF4 using this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
IRF4 Rabbit Polyclonal Antibody
SKU:
CAB1052
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-451 of human IRF4 (NP_002451.2).
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3662
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using IRF4 antibody (CAB1052).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
