The IRF4 Polyclonal Antibody (CAB0524) is a valuable tool for researchers studying the interferon regulatory factor 4 (IRF4) protein. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it suitable for use in Western blot applications. By binding to the IRF4 protein, it enables the detection and analysis of IRF4 in a variety of cell types.IRF4 is a transcription factor that plays a crucial role in the regulation of immune responses, particularly in the differentiation and function of immune cells. It is involved in a wide range of biological processes, including inflammation, immune cell development, and the immune response to pathogens.
The IRF4 Polyclonal Antibody is an essential tool for studying the function and expression of IRF4 in various research areas, such as immunology, cancer biology, and inflammatory diseases.Understanding the role of IRF4 in immune regulation is essential for developing targeted therapies for diseases characterized by dysregulated immune responses. By using the IRF4 Polyclonal Antibody in research, scientists can gain valuable insights into the mechanisms underlying immune dysregulation and identify potential therapeutic targets for the treatment of immune-related disorders.
Product Name:
IRF4 Rabbit Polyclonal Antibody
SKU:
CAB0524
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 150-350 of human IRF4 (NP_002451.2).
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3662
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using IRF4 Rabbit pAb (CAB0524) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
