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IRF3 Monoclonal Antibody [P3F10AT] (CPAB0062)

SKU:
CPAB0062
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
P3F10AT
Applications:
WB
ELISA
€149
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Description

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IRF3 Monoclonal Antibody [P3F10AT] (CPAB0062)

The IRF3 Polyclonal Antibody (CPAB0062) is a vital tool for researchers studying the immune response and antiviral defenses within the body. Raised in rabbits, this antibody is highly specific to human IRF3 protein and is validated for use in various applications, including Western blot analysis. By targeting IRF3, this antibody allows for the detection and analysis of this important transcription factor in different cell types, making it ideal for studies in immunology, virology, and infectious disease research.

IRF3, or interferon regulatory factor 3, plays a key role in regulating the expression of genes involved in the body's response to viral infections. Understanding the activity of IRF3 is crucial for unraveling the mechanisms of antiviral immunity and developing new strategies for combating viral diseases. By utilizing the IRF3 Polyclonal Antibody, researchers can gain valuable insights into the function of this critical transcription factor and its role in orchestrating the immune response to viral invaders.

Product Name:IRF3 Antibody
Product Sku:CPAB0062
Size:5μg
Host Species:Mouse
Immunogen:Anti-human IRF3 mAb, is derived from hybridization of mouse SP2/ myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human IRF3 amino acids 18-166 purified from Ecoli.
Clone:P3F10AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:IRF3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn
Synonyms:IRF-3, IRF3, Interferon Regulatory Factor 3.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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