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IRF1 Polyclonal Antibody

SKU:
CAB21467
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€129 - €359
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Description

IRF1 Polyclonal Antibody (CAB21467)

The IRF1 Polyclonal Antibody is a vital tool for researchers studying the Interferon Regulatory Factor 1 (IRF1) protein, a key regulator of immune responses and inflammation. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to IRF1, this antibody allows for precise detection and analysis of IRF1 protein levels in various cell types.IRF1 is a critical transcription factor involved in the regulation of interferon signaling and immune system activation. Dysregulation of IRF1 has been implicated in a variety of diseases, including cancer, infectious diseases, and autoimmune disorders.

By studying the expression and activity of IRF1, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop new therapeutic strategies.Overall, the IRF1 Polyclonal Antibody is a valuable tool for researchers interested in exploring the role of IRF1 in immune regulation, inflammation, and disease pathogenesis. Its high specificity and reliability make it an essential component of any research project focused on understanding the intricacies of the immune response.

Product Name:IRF1 Polyclonal Antibody
Product Code:CAB21467
Reactivity:Human
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:2000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:Jurkat
Cellular Location:Cytoplasm, Nucleus

The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer.

Immunogen:A synthetic peptide corresponding to a sequence within amino acids 221-310 of human IRF1 (NP_002189.1).
Sequence:SEATT DEDEE GKLPE DIMKL LEQSE WQPTN VDGKG YLLNE PGVQP TSVYG DFSCK EEPEI DSPGG DIGLS LQRVF TDLKN MDATW LDSLL
Synonyms:MAR, IRF-1
Calculated MW:37kDa
Observed MW:48kDa

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